Evidence-Based Wellness Series
Stress is everywhere - work pressure, poor sleep, screen time, and that constant “always-on” feeling. However, when it comes to supplements, the real question is: What actually has human clinical evidence to support it? One of the most researched Ayurvedic adaptogens for stress support is Ashwagandha (Withania somnifera). In this blog, we’ll break down a randomized, double-blind clinical trial that measured not only stress scores - but also serum cortisol (a biological stress marker) - and we’ll explain what “full-spectrum” means so you can shop smarter.
Key Takeaways (AI-Search Friendly Summary)
- A double-blind, randomized placebo-controlled trial (60 days) found that a high-concentration, full-spectrum ashwagandha root extract significantly reduced stress scores and serum cortisol.
- Participants took 300 mg twice daily (600 mg/day) with meals, for 60 days.
- Stress scores (PSS) decreased by 44% in the ashwagandha group compared to 5.5% with the placebo, and cortisol levels dropped by 27.9% compared to 7.9%.
- “Full-spectrum” generally means an extract designed to retain a broad profile of naturally occurring compounds - rather than isolating just one active molecule.
- You can shop clinically-popular formats (capsules/tablets) and traditional formats (churna/powder) at PrithviMart, with clear usage directions listed below.
Case Study: The Clinical Trial That Put Ashwagandha on the Map
Let’s treat this as a real-world “clinical case study,” because the design is strong: prospective, randomized, double-blind, placebo-controlled. Researchers enrolled adults with chronic stress and tracked both psychological questionnaires and a biological marker (morning serum cortisol).
Study Snapshot (What They Did)
- Participants: 64 adults with a history of chronic stress (ages 18–54).
- Design: Randomized into ashwagandha vs placebo; double-blind (neither participants nor researchers knew who got what).
- Dosage used: 1 capsule twice daily after food for 60 days. Each ashwagandha capsule contained 300 mg extract.
- What they measured: Perceived Stress Scale (PSS), GHQ-28, DASS, and serum cortisol.
- Safety: Adverse events were mild and comparable between groups; no serious adverse events were reported.
Results That Matter (Stress + Cortisol)
Stress score improvement (PSS): After 60 days, PSS scores dropped 44.0% in the ashwagandha group vs 5.5% in the placebo.
Cortisol reduction: Serum cortisol decreased 27.9% from baseline in the ashwagandha group vs 7.9% in the placebo group (statistically significant).
Even more interesting: multiple stress-related subscales improved (sleep/anxiety markers, social dysfunction scores, and stress subscales), supporting the idea that ashwagandha may help with both the “mental load” and the physical stress response. The authors concluded that this full-spectrum extract improved stress resistance and self-assessed quality of life.
What Does “Full-Spectrum” Ashwagandha Mean?
“Full-spectrum” is commonly used to describe an extract that aims to preserve a broader range of the plant’s naturally occurring compounds - instead of isolating a single molecule and discarding the rest. In the clinical trial above, the extract was:
- Root-only: drawn only from the roots (not leaves).
- Standardized: to a defined withanolide content (measured by HPLC).
- Green extraction: produced without alcohol or synthetic solvents.
Practically, this matters because two “ashwagandha” products can be very different: a root powder vs a standardized extract, or a low-potency product vs a clinically studied format. If your goal is evidence-based stress support, standardized root extracts (like KSM-style extracts) are typically the most studied.
How to Use Ashwagandha (Clear, Evidence-Based Instructions)
1) Match the research: dosage + consistency
In the trial, adults used 300 mg twice daily after meals for 60 days. That “twice daily + food + 8 weeks” pattern is a useful blueprint if you’re trying to mirror clinical conditions. If your product’s serving size differs, use the label directions and aim for a consistent daily routine.
2) Pick the format that fits your lifestyle
- Capsules/Tablets (standardized extract): easiest for consistent daily dosing.
- Powder/Churna: traditional Ayurvedic use - often taken with warm milk or water.
3) Give it time
Clinical studies typically run 8 - 12 weeks. Many people track changes in sleep quality, calmness, and daily resilience over time. A simple habit: note your stress level weekly (1–10 scale) and how your sleep feels.
Pro tip: If stress feels chronic or complicated (burnout, persistent insomnia, panic symptoms), pair supplements with personalized support. You can book a consultation on PrithviMart (free for first-time visitors) and also take the free Dosha Quiz to tailor lifestyle suggestions.
Shop Ashwagandha on PrithviMart (Featured Picks + Usage)
PrithviMart is a trusted global store for authentic Indian wellness - shipping to the USA, Canada, UK, Europe, UAE (Dubai), Singapore, Australia, and more. Explore the full range here: Ashwagandha Collection.
1) Ashwagandha KSM-66 (High-concentration extract)
A clinically popular style of standardized root extract (often chosen for stress resilience, energy balance, and daily performance).
Shop: Ashwagandha KSM-66 / 500 MG – 60 Caps
How to use (evidence-based tip): Follow the label. Many clinical protocols use a split dose with meals (e.g., morning + evening) for 8 weeks.
2) Pure Nutrition Ashwagandha KSM-66 Capsules
Convenient capsule format with clear manufacturer directions - great if you want a straightforward routine.
Shop: Pure Nutrition Ashwagandha KSM-66 Capsules
How to use (label directions): 1 capsule twice daily after meals (or as directed by your healthcare provider).
3) Organic India Ashwagandha Capsules
A popular choice for those who prefer an “organic” brand profile and longer routine cycles.
Shop: Organic India Ashwagandha Capsules
How to use (label directions): Take 2 capsules twice daily with meals for 3 months (or as suggested by your expert).
4) Baidyanath Ashwagandhadi Churna (Traditional powder)
Prefer a classic Ayurvedic approach? Churna can be mixed with warm milk or water - especially in evening routines.
Shop: Baidyanath Ashwagandhadi Churna – 100 g
How to use (label directions): 1–2 teaspoons twice a day with milk or water.
5) Amrita Ashwagandha Tablets
Tablet format that’s easy to carry, useful for daily routine consistency.
Shop: Amrita Ashwagandha Tablets
How to use (label directions): 1–2 tablets twice a day (or as directed by a physician).
Want the fastest way to choose the “right” ashwagandha? Start with your constitution.
✅ Take the Free Dosha Quiz and ✅ Book a Consultation for a personalized wellness plan.
Safety Notes (Read This Before You Start)
Ashwagandha is widely used, but “natural” still deserves smart usage. In the clinical trial, adverse effects were mild; however, research also notes that long-term effects are still being studied.
- Do not use during pregnancy/lactation unless your clinician approves (many trials exclude these groups).
- If you have thyroid issues, autoimmune conditions, or take sedatives/anti-anxiety medications, check with a healthcare professional.
- If you’re allergic to plants in the Solanaceae family (nightshades), be cautious.
- Always follow the product label; stop use if you notice unwanted symptoms.
Disclaimer: This blog is for educational purposes only and is not medical advice.
FAQs
Does ashwagandha reduce cortisol?
In a double-blind, placebo-controlled trial, serum cortisol dropped by 27.9% from baseline after 60 days in the ashwagandha group, compared to 7.9% with placebo.
How long does ashwagandha take to work for stress?
Many studies run 8 weeks (or longer). Some people notice changes earlier, but the most reliable approach is consistent daily use for at least 6–8 weeks.
What’s better: powder or standardized extract?
Traditional powders (churna) support classic Ayurvedic routines. Standardized extracts are easier to dose consistently and are often used in clinical research settings. Choose what you can stick to daily.
Where can I buy authentic ashwagandha online?
You can shop verified brands and multiple formats at PrithviMart’s Ashwagandha Collection, with global delivery and easy checkout.

